Goody D, Engelmann D, Mikkat S, Gupta SK, Pützer BM.
Identification of novel anti-metastatic drugs targeting oncogenic E2F1:coregulatory complexes by applying a systems pharmacology approach.
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Epigenetic master regulator EPC1 is a decisive factor for E2F1 to silence cell death and activate metastatic gene signatures in response to DNA damage.
A conserved E2F1-activated gene regulatory network encompassing monocarboxylic acid transporter-1, its co-operating antisense lncRNA SLC16A1-AS1 and their common downstream targets mediates bladder cancer invasiveness.