Univ.-Prof. Dr. med. Dr. rer. nat.

Brigitte M. Pützer

Institute Director
(+49) 381 494-5066

Research interest

As molecular biologist and physician, I am a translational scientist interested in transferring basic research findings into individualized therapies. My major interests lie on cancer metastasis, connection between neurogenesis and cancer, tumor stem cell-targeted treatments and cellular programming strategies. Our work concentrates on signaling networks and epigenetic signatures causing tumor progression and heterogeneity, drug resistance as well as the immune-microenvironment and thereby focusses on the E2F1 transcription factor interactome and p53 family members. By using high-throughput omics combined with viral vector and genome editing technologies, we identify molecular alterations in dynamic regulatory processes, apply modeling approaches to predict biomarkers and create custom-made antimetastatic drugs. In the area of gene therapy, the main scope of research is development of smart-adenoviral vector technologies and innovative gene delivery tools for in situ-application. The work of my group provides fundamental new insights into the cellular and molecular principles of tumor metastasis and emphasizes the great utility of molecular therapies.

Academic background

2013–to date
Director, Institute of Experimental Gene Therapy and Cancer Research, University of Rostock, Germany
2003-to date
Full Professor for Vectorology and Experimental Gene Therapy and Head of the Department for Vectorology and Experimental Gene Therapy, Medical Faculty, University of Rostock, Germany
Habilitation and Venialegendi in Molecular Biology, Medical Faculty,University of Essen, Germany
Doctorate in Medicine, Department of Molecular Biology (Tumor Research),University Hospital Essen, Germany
Visiting Assistant Professor, Center of Molecular Medicine, University Cologne, Germany
Assistant Professor, Department of Molecular Biology, University Hospital Essen, Germany
Postdoctoral Fellow, Department of Biology, McMaster University, Ontario, Canada
Research group leader, Department of Molecular Biology (Tumor Research), University Hospital Essen, Germany
Ph.D. in Molecular Biology, Department of Molecular Biology (Tumor Research), University of Essen, Germany
Approbation, University Hospital, Essen, Germany
Assistant doctor, Clinic of bone marrow transplantation, University Hospital, Essen, Germany
Assistant doctor, Institute of Virology, University Medical School, Essen, Germany
Third State exam in Medicine, University of Essen, Germany
Diploma in Biology, Rheinische Friedrich-Wilhelms-Universität Bonn, Germany

Selected publications


Viral Vector, Use There of For Therapy Of Liver Cell Carcinomas And Pharmaceutical Composition Comprising The Vector (PVA1142 DE 10 2005055 128)

European Patent PVA1158EP 1985708/2015 – Selective targeting of virusesto neural precursor cells

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