Projects

Completed Projects

Functional Screening and Target Validation of Long Non-Coding RNAs Regulating EMT and Drug Resistance to Combat E2F1-Induced MiM-Urinary Bladder Carcinoma

2016-2017

Analysis of function and regulation of progranulin and miR-195 on human villous trophoblast cells and its impact on endothelial function

2014-2017

e:Bio Joint Project SysMet: Systems Biology of E2F Signaling in Tumorprogression and Metastasis

2013-2016

The Role of E2F1-regulated microRNAs in Tumor Metastasis and their anti-metastatic therapeutic Potential

2013-2014

Tumor Progression by E2F in orthotopic Metastasis Models – antimetastatic Potential of Effector Genes and Coregulators

2011-2015

Targeted antifibrotic Gene Therapy – Stem Cell Potential of hepatic Stellate Cells

2010-2013

Establishment of a syngenic Tumor Stem Cell (TSC) Mouse Model using in vivo Targeting of adult neural Stem Cells as a Basis for Oncogenomic Analyses and TSC-based Therapies

2010-2012

Tailor-made Adenoviruses for targeted in-Situ Gene Transfer into adult Stem Cells of the CNS

2008-2011

Evaluation of the systemic Therapy Potential of Tumor-specific Adenovirus Vectors in RET transgenic Mouse Model and Xenotransplant-Tumors

2008-2011

The role of adult neural Stem Cells in the Development and Chronification of hyppocampal Epilpsy : Modulation by adenoviral Apoptosis or Proliferation Induction

2009-2010

Functional Relevance of the E2F1 Oncogene for Tumor Progression and Metastasis of Malignant Melanoma

2006-2010

Investigation of the molecular Mechanisms of RET Oncogenes associated Tumorigenesis (Genotype-Phenotype Correlation) as a Basis for Tumor-selective Therapy

2004-2007

Genome-oriented Clinical Research – Functional Genome Research / Organ Modification and Replacement -: Targeting of adult Stem Cells for Transplantation – Development of selective Adenovirus Vectors for Gene Transfer into neural Stem Cells

2003-2006

Development of tumor-selective Adenovirus Vectors for the Treatment of Thyroid Carcinomas

2003-2006

Investigation of Tumorigenesis by N-terminal truncated p73-isoforms in N-p73-transgenic Mice Evaluation of an Interleukin-12/B7.I expressing Helper Virus-dependent adenoviral Vector in non-transplanted HCCs

2002-2006

Evaluation of an Interleukin-12/B7.I expressing Helper Virus-dependent adenoviral Vector in non-transplanted HCCs

2001-2006

Enzymatic Trabeculocanalotomy using Matrix-Metalloprotease (MMP) Gene Transfer and pharmacological Inhibition of its Inhibitors (TIMP)

2001-2004

Inhibition of the RET Proto-oncogene in medullary Thyroid Carcinoma by a Dominant-Negative Mutant and Characterization of tumor suppressive mechanisms

2000-2003

Priority funding program: Apoptosis Deficiency and its Modulation in malignant Diseases – Identification of E2F-regulated Apoptosis-inducing Genes as potential Tumor Suppressor Genes

1999-2005

Gene Therapeutic Intervention in Pancreatic Cancer through adenoviral Transfer of Apoptosis-inducing and immunomodulatory Genes

1999-2001
Menu