Projects
Completed Projects
Functional Screening and Target Validation of Long Non-Coding RNAs Regulating EMT and Drug Resistance to Combat E2F1-Induced MiM-Urinary Bladder Carcinoma
2016-2017
Analysis of function and regulation of progranulin and miR-195 on human villous trophoblast cells and its impact on endothelial function
2014-2017
e:Bio Joint Project SysMet: Systems Biology of E2F Signaling in Tumorprogression and Metastasis
2013-2016
The Role of E2F1-regulated microRNAs in Tumor Metastasis and their anti-metastatic therapeutic Potential
2013-2014
Tumor Progression by E2F in orthotopic Metastasis Models – antimetastatic Potential of Effector Genes and Coregulators
2011-2015
Targeted antifibrotic Gene Therapy – Stem Cell Potential of hepatic Stellate Cells
2010-2013
Establishment of a syngenic Tumor Stem Cell (TSC) Mouse Model using in vivo Targeting of adult neural Stem Cells as a Basis for Oncogenomic Analyses and TSC-based Therapies
2010-2012
Tailor-made Adenoviruses for targeted in-Situ Gene Transfer into adult Stem Cells of the CNS
2008-2011
Evaluation of the systemic Therapy Potential of Tumor-specific Adenovirus Vectors in RET transgenic Mouse Model and Xenotransplant-Tumors
2008-2011
The role of adult neural Stem Cells in the Development and Chronification of hyppocampal Epilpsy : Modulation by adenoviral Apoptosis or Proliferation Induction
2009-2010
Functional Relevance of the E2F1 Oncogene for Tumor Progression and Metastasis of Malignant Melanoma
2006-2010
Investigation of the molecular Mechanisms of RET Oncogenes associated Tumorigenesis (Genotype-Phenotype Correlation) as a Basis for Tumor-selective Therapy
2004-2007
Genome-oriented Clinical Research – Functional Genome Research / Organ Modification and Replacement -: Targeting of adult Stem Cells for Transplantation – Development of selective Adenovirus Vectors for Gene Transfer into neural Stem Cells
2003-2006
Development of tumor-selective Adenovirus Vectors for the Treatment of Thyroid Carcinomas
2003-2006
Investigation of Tumorigenesis by N-terminal truncated p73-isoforms in N-p73-transgenic Mice Evaluation of an Interleukin-12/B7.I expressing Helper Virus-dependent adenoviral Vector in non-transplanted HCCs
2002-2006
Evaluation of an Interleukin-12/B7.I expressing Helper Virus-dependent adenoviral Vector in non-transplanted HCCs
2001-2006
Enzymatic Trabeculocanalotomy using Matrix-Metalloprotease (MMP) Gene Transfer and pharmacological Inhibition of its Inhibitors (TIMP)
2001-2004
Inhibition of the RET Proto-oncogene in medullary Thyroid Carcinoma by a Dominant-Negative Mutant and Characterization of tumor suppressive mechanisms
2000-2003
Priority funding program: Apoptosis Deficiency and its Modulation in malignant Diseases – Identification of E2F-regulated Apoptosis-inducing Genes as potential Tumor Suppressor Genes
1999-2005
Gene Therapeutic Intervention in Pancreatic Cancer through adenoviral Transfer of Apoptosis-inducing and immunomodulatory Genes
1999-2001
