Abstracts
New Horizons in Translational Medicine Volume 4;1-4:48-98.
E2F1 signaling promotes chemoresistance and lymphogenic metastasis in penile cancer revealing new prognostic biomarkers.
Fenner F, Goody D, Protzel C, Erbersdobler A, Richter C, Hartz J, Naumann CM, Kalthoff H, Herchenröder O, Hakenberg OW, Pützer BM.
New Horizons in Translational Medicine Volume 4;1-4:48-98.
Clinical and functional implications of microRNA-182 in RET gene mutation-induced progression of medullary thyroid cancer,
Spitschak A, Meier C, Kowtharapu B, Engelmann D, Pützer BM.
Cancer Res 77(13 Suppl):Abstract nr 1895.
A conserved E2F1-activated gene regulatory network encompassing monocarboxylic acid transporter-1, its co-operating antisense lncRNA SLC16A1-AS1 and their common downstream targets mediates bladder cancer invasiveness.
Jansen BA, Logotheti S, Heckl D, Klusmann J-H, Kozcan D, Taher L, Fuellen G, Engelmann D, Pützer B.
Cancer Res 76(7 Suppl):Abstract nr B27.
Identification of novel anti-metastatic drugs targeting oncogenic E2F1:coregulatory complexes by applying a systems pharmacology approach.
Goody D, Engelmann D, Mikkat S, Gupta SK, Pützer BM.
Cancer Res 76(7 Suppl):Abstract nr B26.
Epigenetic master regulator EPC1 is a decisive factor for E2F1 to silence cell death and activate metastatic gene signatures in response to DNA damage.
Engelmann D, Wang YJ, Alla V, Goody D, Gupta SK, Spitschak A, Pützer BM.
Eur Urol Supplements 04; 13:e52.
MicroRNA expression signature discriminates between metastatic and non-metastatic penile carcinoma.
Hartz JM, Protzel C, Engelmann D, Puetzer BM, Hakenberg OW.
Hum Gene Ther 26:A50-A50.
Novel subventricular zone early progenitor cell-specific adenoviral vector for in brain stem cell bioengineering.
Reetz J, Hildebrandt S, Schmidt A, Meier C, Herchenröder O, Gläser A, Witt M, Pützer BM.
Cancer Res 75(15 Suppl):Abstract nr 4099.
IGF1R signaling connects DNp73-mediated EMT with the acquisition of cancer stem cell properties.
Meier C, Steder M, Hardtstock P, Alla V, Pützer BM.
Geburtshilfe Frauenheilkd 2015; 75:P13.
Untersuchungen zu Funktion und Regulation von Progranulin an humanen villösen Trophoblastzellen und deren Einfluss auf die Endothelzellfunktion.
Szewczyk M, Knoll S, Pützer B, Richter DU, Reimer T, Stubert J.
Mol Ther 2015; 23 (Supplement 1):44-45.
Novel subventricular zone early progenitor cell specific adenovirus for in situ brain stem cell engineering unveils cellular heterogeneity.
Reetz J, Hildebrandt S, Schmidt A, Meier C, Herchenröder O, Gläser A, Witt M, Pützer BM.
JEADV 2017; 31:61-62.
Melanoma-associated hypopigmentation as sign of EMT-propelled metastatic spread: towards identification of the molecular particularities.
Fürst K, Steder, M, Logotheti, S, Marquardt, S, Engelmann D, Pützer, BM.
Geburtshilfe Frauenheilkd 2017; 77(04): 379-395
Parakrine Effekte der trophoblastären Progranulinexpression auf humane umbilikale Endothelzellen in-vitro
Szewczyk M, Spitschak A, Knoll S, Richter DU, Reimer T, Pützer BM, Stubert J
Geburtshilfe Frauenheilkd 2017; 77(04): 379-395
Bedeutung der Sauerstoffkonzentration für die plazentare Progranulinexpression im ersten Trimenon
Szewczyk M, Knoll S, Pützer BM, Richter DU, Reimer T, Stubert J
European Journal of Cancer, 2015; 51, 3: Abstract 347.
A new role of MTA1 in E2F1-mediated tumour progression and invasion.
Goody D, Engelmann D, Mikkat S, Gupta S, Pützer BM.
European Journal of Cancer, 2015; 51, 3: Abstract 190.
Functional screening and target validation of long non-coding RNAs regulating EMT and drug resistance to combat E2F1-induced MiM-urinary bladder carcinoma
Jansen BAH, Heckl D, Taher L, Pützer BM, Engelmann D.
International Journal of Molecular Medicine, 2014; 34, S94: Abstract 458.
Crossing the border: DNp73 in cancer metastasis.
Steder M, Alla V, Emmrich S, Vera J, Pützer BM.
Z Gastroenterol 2013; 51 – P_1_16. DOI: 10.1055/s-0032-1331916.
Adenoviral-mediated specific targeting of hepatic stellate cells as a selective therapeutic approach in liver fibrosis.
Genz B, Reetz J, Meier C, Kowtharapu BS, Stoll A, Timm F, Vollmar B, Pützer B, Abshagen K, Herchenröder O.
Onkologie 2012; 35(suppl 6): 93. Abstract V325
Expression of and CD8+ T cell responses to Wilms´tumor gene 1 (WT1) in patients with AML or MDS after chemotherapy and allogeneic stem cell transplantation.
Casalegno-Garduño R, Meier C, Schmitt A, Hilgendorf I, Rohde S, Spitschak A, Hirt C, Linnebacher M, Pützer B, Freund M, Schmitt M.
Langenbecks Arch Surg. 2011; 396(6):921.
New perspective in the anti-angiogenic treatment of metastatic skin cancer.
Mayrhofer C, Engelmann D, Pützer BM, Vollmar B.
Blood. 2011; 118: Abstract 4315.
Expression of RHAMM and WT1 as well as T cell responses to these antigens before and after allogeneic stem cell transplantation in patients with leukemia.
Casalegno-Garduño R, Meier C, Mani J, Borchert K, Hilgendorf I, Gross Y, Filipowska A, Koczan D, Spitschak A, Linnebacher M, Schmitt A, Greiner J, Freund M, Pützer BM, Schmitt M.
Langenbecks Arch Surg. 2011; 396(6):920.
ZPI-deficiency results in a high thrombosis risk in generalized Shwartzman reaction.
Butschkau A, Nagel P, Grambow E, Pützer BM, Vollmar B.
Langenbecks Arch Surg. 2011; 396(6):890.
Cell specific targeting of hepatic stellate cells as therapeutic approach in liver fibrosis.
Genz B, Fürst K, Abshagen K, Stoll A, Schmidt A, Pützer BM, Vollmar B.
Onkologie. 2011; 34: Supplement 6, 84-84. P299.
Expression of RHAMM and WT1 before and after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML).
Casalegno-Garduño R, Meier C, Mani J, Borchert K, Hilgendorf I, Gross Y, Filipowska A, Koczan D, Spitschak A, Linnebacher M, Schmitt A, Pützer BM, Schmitt M.
J Vasc Res. 2011; 48: Supplement 1, 107-107.
ZPI-deficiency results in a high thrombosis risk in generalized Shwartzman reaction.
Butschkau A, Nagel P, Grambow E, Pützer BM, Vollmar B.
Mol Ther. 2011; 19:Suppl. 1 S160.
Cancer specific peptide-tagged Ad vectors in systemic therapy of aggressive solid tumors.
Schmidt A, Eipel C, Fürst K, Sommer N, Pahnke J, Pützer BM.
Hum Gene Ther 2010; 21:1205-1206.
Specific LNA-ASOs against oncogenic p73 isoforms permit therapeutic cancer targeting in vivo.
Emmrich S, Wang W, John K, Li W, Pützer BM.
Cellular Oncology. 2010; 32(3):189-190.
E2F1 Determines Melanoma Progression and Metastasis via EGF Receptor Signaling.
Alla V, Engelmann D, Niemetz A, Pahnke J, Schmidt A, Kunz M, Emmrich S, Steder M, Koczan D, Pützer BM.
ACTA NEUROPATHOLOGICA. 2009; 118(3):448-448.
Pseudotyped adenoviruses mediate gene transfer for specific intracerebral and intramuscular Exon-Skipping constructs.
Krohn M, Schoeppe T, Schmidt A, Pützer B, Pahnke J.
HUM GENE THER. 2008; 19(10):1103-1103.
Adenovirus-mediated systemic therapy of medullary carcinoma in the thyroid glands of RETC634R transgenic mice through targeted expression of RET-DeltaTK.
Schmidt A, Sommer N, Trübe L, Eipel C, Dahmen U, Pützer BM.
HUM GENE THER. 2008; 19(10):1180-1180.
Specific and long-term genetic engineering of adult stem cells in the rodent brain by peptide-tagged Ad vectors.
Schmidt A, Stoll A, Pahnke J, Hildebrandt S., Wree A, Pützer BM.
Der Pathologe 2008; Supplement 1: S9 Do-023.
The p53 family inhibitor deltaNp73 induces autonomous growth and hepatocarcinogenesis in transgenic mice.
Mundig J, John K, Miše N, Schmidt A, Buhlmann S, Ibrahim SM, Putzer BM, Tannapfel A.
YAKHTEH 2008; 10(5):Supplement 1.
Selective Targeting of Adenoviral Vectors to Neural Precursor Cells in the Hippocampus of Adult Mice: New Prospects for In Situ Gene Therapy.
Pützer BM, Schmidt A, Haas SJP, Eckhoff B, Wree A, Kempermann G, Scheibe J, Hildebrandt S, Racek T.
Hepatology Intl. 2008; 2(2): S42 PL-02.
Differential regulation of hepatitis B virus core promoter/enhancer II by TAp73 and its oncogenic counterpart DNp73: implications for hepatocarcinogenesis.
Buhlmann S, Racek T, John K, Schaefer S, Pützer BM.
Hepatology Intl. 2008; 2(2): S101 PP-080.
Molecular mechanisms of hepatocarcinogenesis in DNp73-Transgenic mice: significance of N-Terminally truncated p73 Species for liver cancer therapy.
John K, Tannapfel A, Miše N, Schmidt A, Buhlmann S, Ibrahim SM, Putzer BM.
Hum Gene Ther. 2007; 18(10):S988 Or84.
Selective transduction of adult neural precursor cells in the mouse dentate gyrus by adenoviral vectors: New prospects to utilize the therapeutic potential of stem cells in the adult brain.
Schmidt A, Haas SJ-P, Hildebrandt S, Racek T, Kempermann G, Wree A, Pützer BM.
Mol Ther. 2006; 13:S362 Suppl. 1.
Adenovirus-mediated TA-p73beta gene transfer leads to chemosensitization of human malignant melanoma.
Tuve S, Racek T, Niemetz A, Schultz J, Soengas MS, Pützer BM.
Thorac Cardiovasc Surg. 2006; 54.
Anti-apoptotic Bcl-2 gene modified rat MSCs improves heart function after myocardial infarction.
Ma N, Li W, Ong LL, Nesselmann C, Pützer B, Choi YH, Kaminski A, Skrabal C, Liebold A, Stamm C, Steinhoff G.
Mol Ther. 2006; 13: S89-S89. ISSN:1525-0016.
Conjugating polymer vector to magnetic nanobeads enhances local gene expression in the heart.
Li W, Ma N, Ong L, Kaminski A, Lorenz P, Putzer BM, Li RK, Stamm C, Steinhoff G.
Mol Ther. 2006; 13: S153-S153 399 Suppl. 1. ISSN: 1525-0016.
Solid nanobeads prevents polycations from entering the nuclei and enhanced transfection efficiency.
Li W, Ma N, Ong L, Kaminski A, Lorenz P, Pützer BM, Li R-K, Stamm C, Steinhoff G.
Mol Ther. 2006; 13: S169 440 Suppl. 1.
Overexpression of Bcl-2 prevented MSCs from apoptosis and improved heart function.
Ma N, Li W, Nesselmann C, Ong L, Kaminski A, Pützer BM, Li R-K, Stamm C, Steinhoff G.
CIRCULATION (Oct 25 2005) Vol. 112 No. 17 Suppl. S pp.U180-U180.
Magnetic nanobeads for local gene delivery: A novel vector for myocardial gene therapy.
Li WZ, Ma N, Kaminski A, Lorenz P, Puetzer B, Stamm C, Steinhoff G.
Thorac Cardiovasc Surg 53, 2005.
Magnetic nanobeads for guided gene delivery to the heart.
Li W, Ma N, Kaminski A, Lorenz P, Pützer B, Stamm C, Steinhoff G.
Thorac Cardiovasc Surg. 2005; 53.
Bcl-2 protects rat MSCs from apoptosis and improves heart function.
Ma N, Li W, Nesselmann C, Li Z, Pützer B, Stamm C, Steinhoff G.
Ophthalmologe 2004; 101:S614-617.
Adenoviraler Gentransfer von p53 hemmt die Proliferation humaner Tenonfibroblasten.
Johnson KTM, Heise K, Steuhl K-P, Rödicker F, Pützer B, Hudde T.
Mol Ther. 2004; 9: S361-S361 943 Suppl. 1.
Loss of neoplastic phenotype by specific inhibition of RET oncogene signalling in a transgenic model of primary medullary thyroid carcinoma.
Drosten M, Hilken G, Rödicker F, Boeckmann M, Theseling CC, Miše N, Cranston AN, Frilling A, Ponder BA, Pützer BM.
Mol Ther. 2004; 9: S236-S236 622 Suppl. 1.
Discovery of targeting peptides for selective therapy of medullary thyroid carcinoma.
Böckmann M, Drosten M, Pützer BM.
J Gene Med. 2003; 5 (3): S15-S15.
Update on adenoviruses and retargeting.
Böckmann M, Pützer BM.
Mol Ther. 2003; 7:1095.
High efficiency of p73 beta in p53-null pancreatic carcinoma resistant against wild-type p53 gene therapy.
Rödicker F, Pützer BM.
Mol Ther. 2003; 7:39.
Inhibition of RET autophosphorylation by adenoviral expressed RET-delta TK: Implications for medullary thyroid carcinoma therapy.
Drosten M, Cranston A, Pollmeier B, Hunke J, Hilken G, Dirsch O, Frilling A, Ponder BA, Pützer BM.
Eur J Cancer 2002 ; 38:490 Suppl 7 Nov.
Inhibition of oncogenic RET signaling by Ad vector-mediated expression of a dominant-negative RET-mutant: implications for medullary thyroid cancer treatment.
Drosten M, Frilling A, Stiewe T, Pützer BM.
Eur J Cancer 2002 ; 38:307 Suppl 7 Nov.
Implications of N-terminal truncated p73 for cancer.
Pützer BM, Stiewe T.
RoeFo 2002 Thema: Wissenschaftliche Vortragsveranstaltungen Wissenschaftliches Vortragsprogramm VO53 Experimentelle Radiologie: Tumoren. Thieme Verlag.
Gentherapie des hepatozellulären Karzinoms (HCC): In-vivo-Evaluation einer adenoviralen Transfektion von Interleukin-12/B7.1 im Murmeltier mittels Magnetresonanz-tomographie (MRT).
Herborn C, Pützer BM, Roggendorf M, Debatin JF, Rühm SG.
Cancer Gene Ther. 2001; 8:PD44.
Large nontransplanted hepatocellular carcinoma in woodchucks: treatment with adenovirus-mediated delivery of interleukin-12/B7.1 genes.
Pützer BM, Stiewe T, Rödicker F, Schildgen O, Rühm S, Dirsch O, Fiedler M, Dahmen U, Tennant B, Scherer C, Graham FL, Roggendorf M.
Mol Ther. 2001; 3:21.
Regression of large nontransplanted hepatocellular carcinoma following adenovirus-mediated interleukin-12/B7.1 gene delivery in woodchucks.
Pützer BM, Stiewe T, Rödicker F, Schildgen O, Rühm S, Dirsch O, Fiedler M, Dahmen U, Tennant B, Scherer C, Graham FL, Roggendorf M..
Eur Surg Res. 2001; 33:107-165 (DOI: 10.1159/000049703)
Influence of Somatostatin Analogues on Medullary Thyroid Carcinoma in vitro.
Tecklenborg K, Frilling A, Weber F, Görges R, Pützer B, Broelsch CE.
J Mol Med. 2001; 79:B38.
Enhanced therapeutic efficacy of gemcitabine in pancreatic cancer by adenovirus mediated E2F1 gene transfer.
Rödicker F, Stiewe T, Pützer BM.
J Mol Med. 2001; 79:B38.
Treatment of large virus-induced primary liver tumors in woodchucks by adenovirus-mediated delivery of IL-12/B7.1 genes.
Rödicker F, Stiewe T, Schildgen O, Rühm S, Dirsch O, Fiedler M, Dahmen U, Tennant B, Scherer C, Graham FL, Roggendorf M, Pützer BM.
J Mol Med. 2001; 79:B39.
Restenosis prevention: successful inhibition of VSMC cell cycle progression by adenovirus-mediated delivery of a pro-apoptotic dominant-negativ E2F1 mutant.
Stiewe T, Köhler K, Erbel R, Pützer BM.
Int J Mol. Med. 2001; 8:S63.
Role of p73 in cancer: Tumor suppressor gene or oncogene?
Stiewe T, Zimmermann S, Theseling C, Esche H, Frilling A, Pützer BM.
Proc Intl Soc Mag Reson Med. 2001; 9.
Magnetic resonance imaging in in vivo-evaluation of hepatocellular carcinomas (HCC) post gene therapy (adenoviral transfection of interleukin-12/B7.1) in woodchucks.
Herborn CU, Pützer BM, Debatin JF, Ruehm SG.
Cancer Gene Ther. 2001; 8:O22.
Adenovirus-mediated E2F1 gene transfer enhances therapeutic efficacy of gemcitabine in pancreatic cancer.
Rödicker F, Pützer BM.
Arch Dermatol Res. 2000: 292:202.
Anti-Cancer Therapy Using Adenovirus Vectors Expressing Immunomodulatory Genes.
Addison CL, Rödicker F, Bramson J, Lowak M, Stiewe T, Zimmermann S, Bolle I, Hilken G, Roggendorf M, Esche H, Graham FL, Pützer BM.
Mol Ther. 2000; 1:143-144
Inducible activation of Ad Vector-delivered toxic transgenes for safe cancer gene therapy.
Stiewe T, Crespo F, Pützer BM.
Cancer Gene Ther. 2000; 7:1398-1398.
Regulation of adenoviral-delivered toxic genes by 4-hydroxy-tamoxifen (4-OHT) binding to the estrogen receptor for safe cancer gene therapy.
Stiewe T, Drosten M, Crespo F, Pützer BM.
J Gene Med. 1999; 1:72.
Development of an adenovirus-vector for tamoxifen-regulated induction of apoptosis by a dominant-negative E2F1-estrogen receptor fusion protein.
Pützer BM, Stiewe T, Crespo F, Esche H.
J Gene Med. 1999; 1:66.
E1A overcomes the apoptosis block in BCR/ABL-positive leukemia cells and renders cells susceptible to induction of apoptosis by chemotherapeutic agents.
Stiewe T, Parssanedjad K, Esche H, Opalka B, Pützer BM.
Cancer Gene Ther. 1997; 4:317-318.
Interleukin-12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression.
Pützer BM, Hitt M, Muller WJ, Emtage P, Gauldie J, Graham FL.
Cancer Gene Ther. 1997; 4:P137-P137 Suppl. S.
Combination therapy with IL-2 and wild-type p53 expressed by Ad-vectors induces tumor regression in vivo without cytokine related toxicity.
Pützer BM, Bramson JL, Addison CL, Muller WJ, Graham FL.
Biochem. Soc Transactions. 1996; 24:S510.
Transformation-defective E1A-products of the Ad12-non-oncogenic host range mutant CS-1 are able to disrupt E2F-containing complexes and to transactivate E2F-motif containing promoters.
Rumpf HM, Gnauk J, Kirch HC, Esche H, Pützer BM.
Exp Hematol. 1995; 23 (8):780-780.
Cell-density dependent growth reduction in interferon alpha-resistant U937 VR unravels different mechanisms of E2F(-1) inactivation.
Kirch HC, Pützer B, Kuhlmann S, Brockmann D, Esche H, Kloke O.
