The research at the Institute of Experimental Gene Therapy and Cancer Research (IEGT) is dedicated towards investigating molecular causes of tumor development, its progression and chemoresistance. These studies are a basis to design novel strategies to combat cancer. Our main interest is focussed on gene expression signatures that promote resistance to apoptosis and metastasis and which are regulated by oncogenic transcripton factors. Heading towards translational oncology, our goal is to identify relevant biomarkers which may eventually be utilized as clinical targets in tumor- and stem cell therapy.