{"id":5233,"date":"2019-10-22T17:31:34","date_gmt":"2019-10-22T15:31:34","guid":{"rendered":"https:\/\/www.iegt-rostock.de\/projekte_iegt\/cardio-specific-ad-vectors\/"},"modified":"2020-09-03T11:30:47","modified_gmt":"2020-09-03T09:30:47","slug":"cardio-specific-ad-vectors","status":"publish","type":"projekte_iegt","link":"https:\/\/www.iegt-rostock.de\/en\/projekte_iegt\/cardio-specific-ad-vectors\/","title":{"rendered":"Development and Application of Optimized Cardio-Specific Ad Vector-based Systems for In Situ Establishment of Biological Pacemakers"},"content":{"rendered":"

Development and Application of Optimized Cardio-Specific Ad Vector-based Systems for In Situ Establishment of Biological Pacemakers<\/h1>\n<\/div><\/div>

This project aims at the development of a \u201cBiological Cardiac Pacemaker\u201d as a therapeutic approach to cure cardiac insufficiencies summarized as Sick-Sinus-Syndrome using murine <\/span>in vitro<\/span><\/i> and <\/span>in vivo<\/span><\/i> models. We intend to generate a biological pacemaker by direct reprogramming of working myocardial cells using optimized programming TF combinations in conjunction with our smart-adenoviruses \u2013 a system that combines newest and safest adenoviral vector (AdV\/HCAdV) technology and individually tailored bispecific adapter proteins. The described concept is scientifically unique and of highest clinical relevance.<\/span><\/p>\n<\/div><\/div>

<\/i><\/div>

Applicant<\/strong><\/p>\n

Prof. Brigitte P\u00fctzer M.D., Ph.D.
\nRostock University Medical Center
\nInstitute of Experimental Gene Therapy and Cancer Research<\/p>\n<\/div><\/div>

<\/i><\/div>

Research Partners<\/strong><\/p>\n

Prof. Robert David
\nUniversity Hospital Rostock
\nReference and Translation Center for Cardiac Stem Cell Therapy<\/p>\n

Prof. Anja Ehrhardt Ph.D.
\nWitten\/Herdecke University
\nInstitute for Virology and Microbiology
\nCenter for Biomedical Education and Research (ZBAF)<\/p>\n<\/div><\/div>

This project is funded by the German Research Foundation (DFG) PU 188\/19-1<\/strong>.<\/p>\n<\/div><\/div><\/div><\/div><\/div>

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