Rumpf HM, Gnauk J, Kirch HC, Esche H, Pützer BM.
Transformation-defective E1A-products of the Ad12-non-oncogenic host range mutant CS-1 are able to disrupt E2F-containing complexes and to transactivate E2F-motif containing promoters.
Biochem. Soc Transactions. 1996; 24:S510.
Cell-density dependent growth reduction in interferon alpha-resistant U937 VR unravels different mechanisms of E2F(-1) inactivation.
Combination therapy with IL-2 and wild-type p53 expressed by Ad-vectors induces tumor regression in vivo without cytokine related toxicity.