Targeting E2F1 death signaling: Opposing role in cancer control and neurodegeneration.

Discov Med. 2006; 6(33):123-127.

Pützer BM.

As with many other molecular agents that are involved in multiple aspects of cellular processes, E2F1 plays a dual role of cellular proliferation and apoptosis. How to take advantage of the apoptosis induction and sensitization properties of E2F1 for therapeutic purposes while minimizing its other properties has a significant bearing on how to turn a functionally complex molecule such as E2F1 into a drug target.

Pubmed

Vorheriger Beitrag

Cancer targeting: impact of oncogenic RET for medullary thyroid carcinoma therapy.

Nächster Beitrag

E2F1 death pathways as targets for cancer therapy.

Targeting E2F1 death signaling: Opposing role in cancer control and neurodegeneration.

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Institut für Experimentelle Gentherapie und Tumorforschung

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