Urinary neopterin concentrations in rhesus monkeys after infection with simian immunodeficiency virus (SIVmac 251).

AIDS. 1989 May;3(5):305-7.

Fendrich C, Lüke W, Stahl-Hennig C, Herchenröder O, Fuchs D, Wachter H, Hunsmann G.

Two rhesus monkeys were infected with SIVmac 251. Elevated urinary neopterin concentrations were observed as the first sign of infection. Virus-specific antibodies were detected 14 days after infection, when neopterin concentrations were already decreasing. The neopterin levels of one animal remained elevated and the virus was repeatedly isolated. Urinary or serum neopterin concentrations appear to be early markers for SIV infection and viremia in rhesus monkeys.

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Experimental infection of macaques with HIV-2ben, a novel HIV-2 isolate.

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Regulation of Ad12 E1A transcription: E2F and ATF motifs in the E1A promoter bind nuclear protein complexes including E2F, DP-1 cyclin A, and/ or RB and mediate transcriptional (auto)activation.

Urinary neopterin concentrations in rhesus monkeys after infection with simian immunodeficiency virus (SIVmac 251).

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