Cancer Res. 2013 Mar 29. [Epub ahead of print]
Kinetic Modeling-Based Detection of Genetic Signatures that Provide Chemoresistance via the E2F1-p73/DNp73-miR-205 Network.
Vera J, Schmitz U, Lai X, Engelmann D, Khan FM, Wolkenhauer O, Pützer BM.
Drug resistance is a major cause of deaths from cancer. E2F1 is a transcription factor involved in cell cycle progression, apoptosis and metastasis through an intricate regulatory network, which includes other transcription factors like p73 and cancer-related microRNAs like miR-205. To investigate the emergence of drug resistance, ...