Pützer BM, Stiewe T, Crespo F, Esche H.
Development of an adenovirus-vector for tamoxifen-regulated induction of apoptosis by a dominant-negative E2F1-estrogen receptor fusion protein.
J Gene Med. 1999; 1:72.
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E1A overcomes the apoptosis block in BCR/ABL-positive leukemia cells and renders cells susceptible to induction of apoptosis by chemotherapeutic agents.
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Regulation of adenoviral-delivered toxic genes by 4-hydroxy-tamoxifen (4-OHT) binding to the estrogen receptor for safe cancer gene therapy.