To fight cancer more effectively it is essential to understand the molecular causes of tumor development, its progression and chemoresistance. Key elements of our ongoing research are oncogenic transcription factors and their regulation of genes which promote resistance to apoptosis and metastasis. Myself, on the one hand, study the transcription factor E2F1 and its effect on DNA repair as a crucial process during tumor development and in chemotherapeutical approaches. On the other hand, I examine the transcription factor p73 and its co-factors in the context of the still poorly understood process of neoneurogenesis in cancer. Analyzing protein-protein interactions of p73 and the resulting down-stream gene signaling may provide new clinical targets in tumor therapy.
RPhD-candidate at IEGT, University Medicine Rostock
Research assistant position at the Deptartment of Cell Biology, University of Rostock Medical Center, Rostock, Germany
Master degree in Medical Biotechnology, University of Rostock Medical Center, Rostock, Germany
Semester Abroad at Umeå University, Umeå, Sweden
Bachelor degree in Human and Molecular Biology, Saarland University, Saarbrücken, Germany
Poster prize at the Ninth Mildred Scheel Cancer Conference
J Exp Clin Cancer Res. 2019 Jul 8;38(1):292. doi: 10.1186/s13046-019-1286-9.