Development and Application of Optimized Cardio-Specific Ad Vector-based Systems for In Situ Establishment of Biological Pacemakers

This project aims at the development of a “Biological Cardiac Pacemaker” as a therapeutic approach to cure cardiac insufficiencies summarized as Sick-Sinus-Syndrome using murine in vitro and in vivo models. We intend to generate a biological pacemaker by direct reprogramming of working myocardial cells using optimized programming TF combinations in conjunction with our smart-adenoviruses – a system that combines newest and safest adenoviral vector (AdV/HCAdV) technology and individually tailored bispecific adapter proteins. The described concept is scientifically unique and of highest clinical relevance.


Prof. Brigitte Pützer M.D., Ph.D.
Rostock University Medical Center
Institute of Experimental Gene Therapy and Cancer Research

Research Partners

Prof. Robert David
University Hospital Rostock
Reference and Translation Center for Cardiac Stem Cell Therapy

Prof. Anja Ehrhardt Ph.D.
Witten/Herdecke University
Institute for Virology and Microbiology
Center for Biomedical Education and Research (ZBAF)

This project is funded by the German Research Foundation (DFG) PU 188/19-1.


Institute of Experimental Gene Therapy and Cancer Research
Core-Facility Viral Vector & Genome-Editing Technologies
Biomedical Research Center
Schillingallee 69
D-18057 Rostock


Ingrid Winkler
    (+49) 381 494-5066
    (+49) 381 494-5062
Department Life, Light & Matter
Research Building LL&M
Albert-Einstein-Str. 25
D-18059 Rostock